When a mosquito bites you (or stabs you with its proboscis, to be proper) it injects saliva that contains enzymes and anticoagulants, which act to speed up its intake of blood. As a response to the saliva, your body will release histamine. Histamine will cause the inflammation of nearby cells which leads to the ensuing itchy, red bump. As we know, this bump will itch, and irritating the bump by itching it will only lead to greater inflammation.
Quick fact: Only female mosquitoes bite humans because they need the nutrients in blood to properly develop their eggs.
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